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Genetic ablation of epidermal EGFR reveals the dynamic origin of adverse effects of anti-EGFR therapy

Cancer patients treated with anti-EGFR drugs often develop a dose-limiting pruritic rash of unknown etiology. The aims of our study were to define causal associations from a clinical study of cutaneous and systemic changes in patients treated with gefitinib and use these to develop and characterize...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Mascia, Francesca, Lam, Gary, Keith, Christopher, Garber, Caroline, Steinberg, Seth M., Kohn, Elise, Yuspa, Stuart H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6324537/
https://ncbi.nlm.nih.gov/pubmed/23966299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3005773
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