Pharmacological Inhibition of Caspase-1 Ameliorates Cisplatin-Induced Nephrotoxicity through Suppression of Apoptosis, Oxidative Stress, and Inflammation in Mice

Caspase-1 is a proinflammatory caspase responsible for the proteolytic conversion of the precursor forms of interleukin-1β to its active form and plays an important role in the pathogenesis of various inflammatory diseases. It was reported that genetic deficiency of caspase-1 prevented cisplatin-ind...

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Bibliographische Detailangaben
Veröffentlicht in:Mediators Inflamm
Hauptverfasser: Kim, Jung-Yeon, Park, Jae-Hyung, Kim, Kiryeong, Jo, Jungmin, Leem, Jaechan, Park, Kwan-Kyu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6323438/
https://ncbi.nlm.nih.gov/pubmed/30670928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/6571676
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