SGLT1 in pancreatic α cells regulates glucagon secretion in mice, possibly explaining the distinct effects of SGLT2 inhibitors on plasma glucagon levels

OBJECTIVES: It is controversial whether sodium glucose transporter (SGLT) 2 inhibitors increase glucagon secretion via direct inhibition of SGLT2 in pancreatic α cells. The role of SGLT1 in α cells is also unclear. We aimed to elucidate these points that are important not only for basic research but...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Suga, Takayoshi, Kikuchi, Osamu, Kobayashi, Masaki, Matsui, Sho, Yokota-Hashimoto, Hiromi, Wada, Eri, Kohno, Daisuke, Sasaki, Tsutomu, Takeuchi, Kazusane, Kakizaki, Satoru, Yamada, Masanobu, Kitamura, Tadahiro
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6323192/
https://ncbi.nlm.nih.gov/pubmed/30416006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2018.10.009
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