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Biodegradable Simvastatin-Containing Polymeric Prodrugs with Improved Drug Release

Simvastatin was previously converted to a polymeric prodrug with higher drug loading, but the hydrophobic nature of the poly(simvastatin) component of the block copolymer led to slow release of the drug in vitro. In this study, we hypothesized that degradation could be accelerated by chemically modi...

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Bibliografiske detaljer
Udgivet i:ACS Biomater Sci Eng
Main Authors: Liyanage, A.D. Thilanga, Chen, Alexander J., Puleo, David A.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6322697/
https://ncbi.nlm.nih.gov/pubmed/30631799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsbiomaterials.8b00884
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