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Biodegradable Simvastatin-Containing Polymeric Prodrugs with Improved Drug Release
Simvastatin was previously converted to a polymeric prodrug with higher drug loading, but the hydrophobic nature of the poly(simvastatin) component of the block copolymer led to slow release of the drug in vitro. In this study, we hypothesized that degradation could be accelerated by chemically modi...
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| Udgivet i: | ACS Biomater Sci Eng |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6322697/ https://ncbi.nlm.nih.gov/pubmed/30631799 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsbiomaterials.8b00884 |
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