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Biodegradable Simvastatin-Containing Polymeric Prodrugs with Improved Drug Release

Simvastatin was previously converted to a polymeric prodrug with higher drug loading, but the hydrophobic nature of the poly(simvastatin) component of the block copolymer led to slow release of the drug in vitro. In this study, we hypothesized that degradation could be accelerated by chemically modi...

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Bibliografski detalji
Izdano u:ACS Biomater Sci Eng
Glavni autori: Liyanage, A.D. Thilanga, Chen, Alexander J., Puleo, David A.
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6322697/
https://ncbi.nlm.nih.gov/pubmed/30631799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsbiomaterials.8b00884
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