Simvastatin Prodrug Micelles Target Fracture and Improve Healing

Simvastatin (SIM), a widely used anti-lipidaemic drug, has been identified as a bone anabolic agent. Its poor water solubility and the lack of distribution to the skeleton, however, have limited its application in the treatment of bone metabolic diseases. In this study, an amphiphilic macromolecular...

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Detalhes bibliográficos
Publicado no:J Control Release
Main Authors: Jia, Zhenshan, Zhang, Yijia, Chen, Yen Hsun, Dusad, Anand, Yuan, Hongjiang, Ren, Ke, Li, Fei, Fehringer, Edward V., Purdue, P. Edward, Goldring, Steven R., Daluiski, Aaron, Wang, Dong
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4315241/
https://ncbi.nlm.nih.gov/pubmed/25542644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2014.12.028
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