The Evaluation Of Therapeutic Efficacy and Safety Profile of Simvastatin Prodrug Micelles in a Closed Fracture Mouse Model

PURPOSE: To evaluate the therapeutic efficiency of a micellar prodrug formulation of simvastatin (SIM/SIM-mPEG) and explore its safety in a closed femoral fracture mouse model. METHODS: The amphiphilic macromolecular prodrug of simvastatin (SIM-mPEG) was synthesized and formulated together with free...

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Vydáno v:Pharm Res
Hlavní autoři: Zhang, Yijia, Jia, Zhenshan, Yuan, Hongjiang, Dusad, Anand, Ren, Ke, Wei, Xin, Fehringer, Edward V., Purdue, P. Edward, Daluiski, Aaron, Goldring, Steven R., Wang, Dong
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4945391/
https://ncbi.nlm.nih.gov/pubmed/27164897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-016-1932-2
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