Structural Optimization of HPMA Copolymer-based Dexamethasone Prodrug for Improved Treatment of Inflammatory Arthritis

Despite their notorious adverse effects, glucocorticoids (GC, potent anti-inflammatory drugs) are used extensively in clinical management of rheumatoid arthritis (RA) and other chronic inflammatory diseases. To achieve a sustained therapeutic efficacy and reduced toxicities, macromolecular GC prodru...

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Detalhes bibliográficos
Publicado no:J Control Release
Main Authors: Jia, Zhenshan, Zhao, Gang, Wei, Xin, Kong, Dexuan, Sun, Yuanyuan, Zhou, You, Lele, Subodh M., Fehringer, Edward V., Garvin, Kevin L., Goldring, Steven R., Wang, Dong
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7429277/
https://ncbi.nlm.nih.gov/pubmed/32445658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2020.05.028
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