Synthesis and Evaluation of a Well-defined HPMA Copolymer-Dexamethasone Conjugate for Effective Treatment of Rheumatoid Arthritis

PURPOSE: To develop a pH-sensitive dexamethasone (Dex)-containing N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer conjugate with well-defined structure for the improved treatment of rheumatoid arthritis (RA). METHODS: A new pH-sensitive Dex-containing monomer (MA-Gly-Gly-NHN=Dex) was synthesized...

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Main Authors: Liu, Xin-Ming, Quan, Ling-Dong, Tian, Jun, Alnouti, Yazen, Fu, Kai, Thiele, Geoffrey M., Wang, Dong
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2008
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2593120/
https://ncbi.nlm.nih.gov/pubmed/18649124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-008-9683-3
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