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Synthesis and Evaluation of a Well-defined HPMA Copolymer-Dexamethasone Conjugate for Effective Treatment of Rheumatoid Arthritis
PURPOSE: To develop a pH-sensitive dexamethasone (Dex)-containing N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer conjugate with well-defined structure for the improved treatment of rheumatoid arthritis (RA). METHODS: A new pH-sensitive Dex-containing monomer (MA-Gly-Gly-NHN=Dex) was synthesized...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2593120/ https://ncbi.nlm.nih.gov/pubmed/18649124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-008-9683-3 |
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