Paternal Exposure to Cyclophosphamide Affects the Progression of Sperm Chromatin Decondensation and Activates a DNA Damage Response in the Prepronuclear Rat Zygote(1)

Spermatozoon decondensation in the zygote leads to the initiation of chromatin remodeling during which protamines are removed and replaced with maternal histones. We hypothesize that damage to male germ cells induced by paternal exposure to cyclophosphamide may alter the timing of spermatozoal decon...

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Dettagli Bibliografici
Pubblicato in:Biol Reprod
Autori principali: Grenier, Lisanne, Robaire, Bernard, Hales, Barbara F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2010
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6322429/
https://ncbi.nlm.nih.gov/pubmed/20393171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1095/biolreprod.109.083345
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