Paternal Exposure to Cyclophosphamide Affects the Progression of Sperm Chromatin Decondensation and Activates a DNA Damage Response in the Prepronuclear Rat Zygote(1)

Spermatozoon decondensation in the zygote leads to the initiation of chromatin remodeling during which protamines are removed and replaced with maternal histones. We hypothesize that damage to male germ cells induced by paternal exposure to cyclophosphamide may alter the timing of spermatozoal decon...

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Bibliographic Details
Published in:Biol Reprod
Main Authors: Grenier, Lisanne, Robaire, Bernard, Hales, Barbara F.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6322429/
https://ncbi.nlm.nih.gov/pubmed/20393171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1095/biolreprod.109.083345
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