Human Norovirus Epitope D Plasticity Allows Escape from Antibody Immunity without Loss of Capacity for Binding Cellular Ligands

Emergent strains of human norovirus seed pandemic waves of disease. These new strains have altered ligand binding and antigenicity characteristics. Study of viral variants isolated from immunosuppressed patients with long-term norovirus infection indicates that initial virus in vivo evolution occurs...

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Bibliografische gegevens
Gepubliceerd in:J Virol
Hoofdauteurs: Lindesmith, Lisa C., Brewer-Jensen, Paul D., Mallory, Michael L., Yount, Boyd, Collins, Matthew H., Debbink, Kari, Graham, Rachel L., Baric, Ralph S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2019
Onderwerpen:
Pathogenesis and Immunity
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6321922/
https://ncbi.nlm.nih.gov/pubmed/30355694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01813-18
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