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Evaluation of β-Sitosterol Loaded PLGA and PEG-PLA Nanoparticles for Effective Treatment of Breast Cancer: Preparation, Physicochemical Characterization, and Antitumor Activity

β-Sitosterol (β-Sit) is a dietary phytosterol with demonstrated anticancer activity against a panel of cancers, but its poor solubility in water limits its bioavailability and therapeutic efficacy. In this study, poly(lactide-co-glycolic acid) (PLGA) and block copolymers of poly(ethylene glycol)-blo...

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Détails bibliographiques
Publié dans:Pharmaceutics
Auteurs principaux: Andima, Moses, Costabile, Gabriella, Isert, Lorenz, Ndakala, Albert J., Derese, Solomon, Merkel, Olivia M.
Format: Artigo
Langue:Inglês
Publié: MDPI 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6321471/
https://ncbi.nlm.nih.gov/pubmed/30445705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics10040232
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