TP53INP1 deficiency maintains murine B lymphopoiesis in aged bone marrow through redox-controlled IL-7R/STAT5 signaling

Bone marrow (BM) produces all blood and immune cells deriving from hematopoietic stem cells (HSCs). The decrease of immune cell production during aging is one of the features of immunosenescence. The impact of redox dysregulation in BM aging is still poorly understood. Here we use TP53INP1-deficient...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Zidi, Bochra, Vincent-Fabert, Christelle, Pouyet, Laurent, Seillier, Marion, Vandevelde, Amelle, N’guessan, Prudence, Poplineau, Mathilde, Guittard, Geoffrey, Mancini, Stéphane J. C., Duprez, Estelle, Carrier, Alice
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2019
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6320535/
https://ncbi.nlm.nih.gov/pubmed/30559202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1809980116
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