TP53INP1 deficiency maintains murine B lymphopoiesis in aged bone marrow through redox-controlled IL-7R/STAT5 signaling

Bone marrow (BM) produces all blood and immune cells deriving from hematopoietic stem cells (HSCs). The decrease of immune cell production during aging is one of the features of immunosenescence. The impact of redox dysregulation in BM aging is still poorly understood. Here we use TP53INP1-deficient...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Zidi, Bochra, Vincent-Fabert, Christelle, Pouyet, Laurent, Seillier, Marion, Vandevelde, Amelle, N’guessan, Prudence, Poplineau, Mathilde, Guittard, Geoffrey, Mancini, Stéphane J. C., Duprez, Estelle, Carrier, Alice
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2019
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6320535/
https://ncbi.nlm.nih.gov/pubmed/30559202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1809980116
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