TP53INP1 deficiency maintains murine B lymphopoiesis in aged bone marrow through redox-controlled IL-7R/STAT5 signaling

Bone marrow (BM) produces all blood and immune cells deriving from hematopoietic stem cells (HSCs). The decrease of immune cell production during aging is one of the features of immunosenescence. The impact of redox dysregulation in BM aging is still poorly understood. Here we use TP53INP1-deficient...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Zidi, Bochra, Vincent-Fabert, Christelle, Pouyet, Laurent, Seillier, Marion, Vandevelde, Amelle, N’guessan, Prudence, Poplineau, Mathilde, Guittard, Geoffrey, Mancini, Stéphane J. C., Duprez, Estelle, Carrier, Alice
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2019
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6320535/
https://ncbi.nlm.nih.gov/pubmed/30559202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1809980116
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