Inter-tumoral heterogeneity of CD3(+) and CD8(+) T-cell densities in the microenvironment of DNA mismatch repair-deficient colon cancers: implications for prognosis

BACKGROUND: Colorectal cancers with deficient DNA mismatch repair (dMMR) are presumed to uniformly have dense lymphocytic infiltration that underlies their favorable prognosis and is critical to their responsiveness to immunotherapy, as compared to MMR-proficient (pMMR) tumors. We examined T-cell de...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Yoon, Harry H., Shi, Qian, Heying, Erica N., Muranyi, Andrea, Bredno, Joerg, Ough, Faith, Djalilvand, Azita, Clements, June, Bowermaster, Rebecca, Liu, Wen-Wei, Barnes, Michael, Alberts, Steven R., Shanmugam, Kandavel, Sinicrope, Frank A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6320300/
https://ncbi.nlm.nih.gov/pubmed/30301825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-1984
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