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Mutation-Specific Antibody Detects Mutant BRAF(V600E) Protein Expression in Human Colon Carcinomas

BACKGROUND: A point mutation (V600E) in the BRAF oncogene is a prognostic biomarker and may predict for non response to anti-EGFR antibody therapy in colon carcinomas. BRAF(V600E) mutations are also frequently detected in tumors with microsatellite instability and indicate a sporadic origin. Using a...

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Detalhes bibliográficos
Main Authors: Sinicrope, Frank A., Smyrk, Thomas C., Tougeron, David, Thibodeau, Stephen N., Singh, Shalini, Muranyi, Andrea, Shanmugam, Kandavel, Grogan, Thomas M., Alberts, Steven R., Shi, Qian
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3720760/
https://ncbi.nlm.nih.gov/pubmed/23657789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.28133
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