Microfluidic Mobility Shift Profiling of Lysine Acetyltransferases Enables Screening and Mechanistic Analysis of Cellular Acetylation Inhibitors

Lysine acetyltransferases (KATs) are critical regulators of signaling in many diseases, including cancer. A major challenge in establishing the targetable functions of KATs in disease is a lack of well-characterized, cell-active KAT inhibitors. To confront this challenge, here we report a microfluid...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:ACS Chem Biol
Autores principales: Sorum, Alexander W., Shrimp, Jonathan H., Roberts, Allison M., Montgomery, David C., Tiwari, Neil K., Lal-Nag, Madhu, Simeonov, Anton, Jadhav, Ajit, Meier, Jordan L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6320249/
https://ncbi.nlm.nih.gov/pubmed/26428393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00709
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares