Microfluidic Mobility Shift Profiling of Lysine Acetyltransferases Enables Screening and Mechanistic Analysis of Cellular Acetylation Inhibitors

Lysine acetyltransferases (KATs) are critical regulators of signaling in many diseases, including cancer. A major challenge in establishing the targetable functions of KATs in disease is a lack of well-characterized, cell-active KAT inhibitors. To confront this challenge, here we report a microfluid...

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Veröffentlicht in:ACS Chem Biol
Hauptverfasser: Sorum, Alexander W., Shrimp, Jonathan H., Roberts, Allison M., Montgomery, David C., Tiwari, Neil K., Lal-Nag, Madhu, Simeonov, Anton, Jadhav, Ajit, Meier, Jordan L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6320249/
https://ncbi.nlm.nih.gov/pubmed/26428393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00709
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