Neutrophil cytoplasts induce Th17 differentiation and skew inflammation toward neutrophilia in severe asthma

Severe asthma is a debilitating and treatment refractory disease. As many as half of these patients have complex neutrophil predominant lung inflammation that is distinct from milder asthma with type 2 eosinophilic inflammation. New insights into severe asthma pathogenesis are needed. Here, concomit...

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Publicat a:Sci Immunol
Autors principals: Krishnamoorthy, Nandini, Douda, David N., Brüggemann, Thayse R., Ricklefs, Isabell, Duvall, Melody G., Abdulnour, Raja-Elie E., Martinod, Kimberly, Tavares, Luciana, Wang, Xiao, Cernadas, Manuela, Israel, Elliot, Mauger, David T., Bleecker, Eugene R., Castro, Mario, Erzurum, Serpil C., Gaston, Benjamin M., Jarjour, Nizar N., Wenzel, Sally, Dunican, Eleanor, Fahy, John V., Irimia, Daniel, Wagner, Denisa D., Levy, Bruce D.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6320225/
https://ncbi.nlm.nih.gov/pubmed/30076281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aao4747
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