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Probing the modularity of megasynthases by rational engineering of a fatty acid synthase Type I
Modularity is a fundamental property of megasynthases such as polyketide synthases (PKSs). In this study, we exploit the close resemblance between PKSs and animal fatty acid synthase (FAS) to re‐engineer animal FAS to probe the modularity of the FAS/PKS family. Guided by sequence and structural info...
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| Udgivet i: | Protein Sci |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
John Wiley and Sons Inc.
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6319764/ https://ncbi.nlm.nih.gov/pubmed/30394635 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3550 |
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