Continuous and bolus intraventricular topotecan prolong survival in a mouse model of leptomeningeal medulloblastoma

Leptomeningeal metastasis remains a difficult clinical challenge. Some success has been achieved by direct administration of therapeutics into the cerebrospinal fluid (CSF) circumventing limitations imposed by the blood brain barrier. Here we investigated continuous infusion versus bolus injection o...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Shackleford, Gregory M., Mahdi, Min Y., Moats, Rex A., Hawes, Debra, Tran, Hung C., Finlay, Jonathan L., Hoang, Tuan Q., Meng, Ellis F., Erdreich-Epstein, Anat
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6319703/
https://ncbi.nlm.nih.gov/pubmed/30608927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0206394
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