TRAIL stabilization and cancer cell sensitization to its pro-apoptotic activity achieved through genetic fusion with arginine deiminase

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) binds to death receptors and induces apoptosis in various cancer cell lines while sparing normal cells. Recombinant TRAIL has shown good safety and efficacy profiles in preclinical cancer models. However, clinical success has been...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Brin, Elena, Wu, Katherine, Dagostino, Eleanor, Meng-Chiang Kuo, Mario, He, Yudou, Shia, Wei-Jong, Chen, Li-Chang, Stempniak, Mariusz, Hickey, Richard, Almassy, Robert, Showalter, Richard, Thomson, James
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6319333/
https://ncbi.nlm.nih.gov/pubmed/30651925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26398
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