TRAIL stabilization and cancer cell sensitization to its pro-apoptotic activity achieved through genetic fusion with arginine deiminase

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) binds to death receptors and induces apoptosis in various cancer cell lines while sparing normal cells. Recombinant TRAIL has shown good safety and efficacy profiles in preclinical cancer models. However, clinical success has been...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Oncotarget
Asıl Yazarlar: Brin, Elena, Wu, Katherine, Dagostino, Eleanor, Meng-Chiang Kuo, Mario, He, Yudou, Shia, Wei-Jong, Chen, Li-Chang, Stempniak, Mariusz, Hickey, Richard, Almassy, Robert, Showalter, Richard, Thomson, James
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Impact Journals LLC 2018
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6319333/
https://ncbi.nlm.nih.gov/pubmed/30651925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26398
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