TRAIL stabilization and cancer cell sensitization to its pro-apoptotic activity achieved through genetic fusion with arginine deiminase

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) binds to death receptors and induces apoptosis in various cancer cell lines while sparing normal cells. Recombinant TRAIL has shown good safety and efficacy profiles in preclinical cancer models. However, clinical success has been...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Brin, Elena, Wu, Katherine, Dagostino, Eleanor, Meng-Chiang Kuo, Mario, He, Yudou, Shia, Wei-Jong, Chen, Li-Chang, Stempniak, Mariusz, Hickey, Richard, Almassy, Robert, Showalter, Richard, Thomson, James
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2018
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6319333/
https://ncbi.nlm.nih.gov/pubmed/30651925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26398
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