Structural stability of purified human CFTR is systematically improved by mutations in nucleotide binding domain 1

The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is an ABC transporter containing two transmembrane domains forming a chloride ion channel, and two nucleotide binding domains (NBD1 and NBD2). CFTR has presented a formidable challenge to obtain monodisperse, biophysically stable protein...

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Vydáno v:Biochim Biophys Acta Biomembr
Hlavní autoři: Yang, Zhengrong, Hildebrandt, Ellen, Jiang, Fan, Aleksandrov, Andrei, Khazanov, Netaly, Zhou, Qingxian, An, Jianli, Mezzell, Andrew T., Xavier, Bala M., Ding, Haitao, Riordan, John R., Senderowitz, Hanoch, Kappes, John C., Brouillette, Christie G., Urbatsch, Ina L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6319260/
https://ncbi.nlm.nih.gov/pubmed/29425673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2018.02.006
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