The non-canonical SMC protein SmcHD1 antagonises TAD formation and compartmentalisation on the inactive X chromosome

The inactive X chromosome (Xi) in female mammals adopts an atypical higher-order chromatin structure, manifested as a global loss of local topologically associated domains (TADs), A/B compartments and formation of two mega-domains. Here we demonstrate that the non-canonical SMC family protein, SmcHD...

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書誌詳細
出版年:Nat Commun
主要な著者: Gdula, Michal R., Nesterova, Tatyana B., Pintacuda, Greta, Godwin, Jonathan, Zhan, Ye, Ozadam, Hakan, McClellan, Michael, Moralli, Daniella, Krueger, Felix, Green, Catherine M., Reik, Wolf, Kriaucionis, Skirmantas, Heard, Edith, Dekker, Job, Brockdorff, Neil
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2019
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6318279/
https://ncbi.nlm.nih.gov/pubmed/30604745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07907-2
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