Hypermethylated gene ANKDD1A is a candidate tumor suppressor that interacts with FIH1 and decreases HIF1α stability to inhibit cell autophagy in the glioblastoma multiforme hypoxia microenvironment

Ectopic epigenetic mechanisms play important roles in facilitating tumorigenesis. Here, we first demonstrated that ANKDD1A is a functional tumor suppressor gene, especially in the hypoxia microenvironment. ANKDD1A directly interacts with FIH1 and inhibits the transcriptional activity of HIF1α by upr...

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Veröffentlicht in:Oncogene
Hauptverfasser: Feng, Jianbo, Zhang, Yan, She, Xiaoling, Sun, Yingnan, Fan, Li, Ren, Xing, Fu, Haijuan, Liu, Changhong, Li, Peiyao, Zhao, Chunhua, Liu, Qiang, Liu, Qing, Li, Guiyuan, Wu, Minghua
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6318269/
https://ncbi.nlm.nih.gov/pubmed/30082910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0423-9
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