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Novel Therapy for Glioblastoma Multiforme by Restoring LRRC4 in Tumor Cells: LRRC4 Inhibits Tumor-Infitrating Regulatory T Cells by Cytokine and Programmed Cell Death 1-Containing Exosomes
Glioblastoma multiforme (GBM) is a heterogeneous malignant brain tumor, the pathological incidence of which induces the accumulation of tumor-infiltrating lymphocytes (TILs). As a tumor suppressor gene, LRRC4 is absent in GBM cells. Here, we report that the recovery of LRRC4 in GBM cells inhibited t...
Zapisane w:
Wydane w: | Front Immunol |
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Główni autorzy: | , , , , , , , , , , , , |
Format: | Artigo |
Język: | Inglês |
Wydane: |
Frontiers Media S.A.
2017
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Hasła przedmiotowe: | |
Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5732324/ https://ncbi.nlm.nih.gov/pubmed/29312296 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01748 |
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