Novel Therapy for Glioblastoma Multiforme by Restoring LRRC4 in Tumor Cells: LRRC4 Inhibits Tumor-Infitrating Regulatory T Cells by Cytokine and Programmed Cell Death 1-Containing Exosomes

Glioblastoma multiforme (GBM) is a heterogeneous malignant brain tumor, the pathological incidence of which induces the accumulation of tumor-infiltrating lymphocytes (TILs). As a tumor suppressor gene, LRRC4 is absent in GBM cells. Here, we report that the recovery of LRRC4 in GBM cells inhibited t...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Li, Peiyao, Feng, Jianbo, Liu, Yang, Liu, Qiang, Fan, Li, Liu, Qing, She, Xiaoling, Liu, Changhong, Liu, Tao, Zhao, Chunhua, Wang, Wei, Li, Guiyuan, Wu, Minghua
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5732324/
https://ncbi.nlm.nih.gov/pubmed/29312296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01748
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