RNase H1 directs origin-specific initiation of DNA replication in human mitochondria

Human mitochondrial DNA (mtDNA) replication is first initiated at the origin of H-strand replication. The initiation depends on RNA primers generated by transcription from an upstream promoter (LSP). Here we reconstitute this process in vitro using purified transcription and replication factors. The...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Posse, Viktor, Al-Behadili, Ali, Uhler, Jay P., Clausen, Anders R., Reyes, Aurelio, Zeviani, Massimo, Falkenberg, Maria, Gustafsson, Claes M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6317783/
https://ncbi.nlm.nih.gov/pubmed/30605451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007781
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