The mGluR5 positive allosteric modulator VU0409551 improves synaptic plasticity and memory of a mouse model of Huntington’s disease

Huntington’s Disease (HD) is an autosomal-dominant neurodegenerative disorder, characterized by involuntary body movements, cognitive impairment, and psychiatric disorder. The metabotropic glutamate receptor 5 (mGluR5) plays an important role in HD and we have recently demonstrated that mGluR5-posit...

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Vydáno v:J Neurochem
Hlavní autoři: Doria, Juliana G., de Souza, Jessica M., Silva, Flavia R., Olmo, Isabella G., Carvalho, Toniana G., Alves-Silva, Juliana, Ferreira-Vieira, Talita H., Santos, Jessica T., Xavier, Claudymara Q. S., Silva, Nathalia C., Maciel, Esther M. A., Conn, Peter Jeffrey, Ribeiro, Fabiola M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6317718/
https://ncbi.nlm.nih.gov/pubmed/30028018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.14555
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