Metal-free ribonucleotide reduction powered by a DOPA radical in Mycoplasma pathogens

Ribonucleotide reductase (RNR) catalyzes the only known de-novo pathway for production of all four deoxyribonucleotides required for DNA synthesis1,2. It is essential for all organisms with DNA as genetic material and a current drug target3,4. Since the discovery that iron is required for function i...

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Udgivet i:Nature
Main Authors: Srinivas, Vivek, Lebrette, Hugo, Lundin, Daniel, Kutin, Yuri, Sahlin, Margareta, Lerche, Michael, Eirich, Jürgen, Branca, Rui M. M., Cox, Nicholas, Sjöberg, Britt-Marie, Högbom, Martin
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6317698/
https://ncbi.nlm.nih.gov/pubmed/30429545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0653-6
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