The MEK Inhibitor Trametinib Ameliorates Kidney Fibrosis by Suppressing ERK1/2 and mTORC1 Signaling

BACKGROUND: During kidney fibrosis, a hallmark and promoter of CKD (regardless of the underlying renal disorder leading to CKD), the extracellular-regulated kinase 1/2 (ERK1/2) pathway, is activated and has been implicated in the detrimental differentiation and expansion of kidney fibroblasts. An ER...

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Bibliographic Details
Published in:J Am Soc Nephrol
Main Authors: Andrikopoulos, Petros, Kieswich, Julius, Pacheco, Sabrina, Nadarajah, Luxme, Harwood, Steven Michael, O'Riordan, Caroline E., Thiemermann, Christoph, Yaqoob, Muhammad M.
Format: Artigo
Language:Inglês
Published: American Society of Nephrology 2019
Subjects:
Basic Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6317609/
https://ncbi.nlm.nih.gov/pubmed/30530834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2018020209
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