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Quantifying Homologous Proteins and Proteoforms

Many proteoforms—arising from alternative splicing, post-translational modifications (PTM), or paralogous genes—have distinct biological functions, such as histone PTM proteoforms. However, their quantification by existing bottom-up mass-spectrometry (MS) methods is undermined by peptide-specific bi...

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Detalhes bibliográficos
Publicado no:Mol Cell Proteomics
Main Authors: Malioutov, Dmitry, Chen, Tianchi, Airoldi, Edoardo, Jaffe, Jacob, Budnik, Bogdan, Slavov, Nikolai
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6317479/
https://ncbi.nlm.nih.gov/pubmed/30282776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.TIR118.000947
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