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6’-Fluoro[4.3.0]bicyclo nucleic acid: synthesis, biophysical properties and molecular dynamics simulations
Here we report on the synthesis, biophysical properties and molecular modeling of oligonucleotides containing unsaturated 6’-fluoro[4.3.0]bicyclo nucleotides (6’F-bc(4,3)-DNA). Two 6’F-bc(4,3) phosphoramidite building blocks (T and C) were synthesized starting from a previously described [3.3.0]bicy...
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| Publicado no: | Beilstein J Org Chem |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Beilstein-Institut
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6317435/ https://ncbi.nlm.nih.gov/pubmed/30643586 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.14.288 |
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