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Synthesis, biophysical properties, and RNase H activity of 6’-difluoro[4.3.0]bicyclo-DNA

Here we present the synthesis, the biophysical properties, and the RNase H profile of 6’-difluorinated [4.3.0]bicyclo-DNA (6’-diF-bc(4,3)-DNA). The difluorinated thymidine phosphoramidite building block was synthesized starting from an already known gem-difluorinated tricyclic glycal. This tricyclic...

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Bibliografske podrobnosti
izdano v:Beilstein J Org Chem
Main Authors: Frei, Sibylle, Katolik, Adam K, Leumann, Christian J
Format: Artigo
Jezik:Inglês
Izdano: Beilstein-Institut 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6334804/
https://ncbi.nlm.nih.gov/pubmed/30680042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.15.9
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