Identifying Attributes That Influence In Vitro-to-In Vivo Concordance by Comparing In Vitro Tox21 Bioactivity Versus In Vivo DrugMatrix Transcriptomic Responses Across 130 Chemicals

Recent efforts aimed at integrating in vitro high-throughput screening (HTS) data into chemical toxicity assessments are necessitating increased understanding of concordance between chemical-induced responses observed in vitro versus in vivo. This investigation set out to (1) measure concordance bet...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: Klaren, William D, Ring, Caroline, Harris, Mark A, Thompson, Chad M, Borghoff, Susan, Sipes, Nisha S, Hsieh, Jui-Hua, Auerbach, Scott S, Rager, Julia E
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Tox21 IN VITRO TO IN VIVO CONCORDANCE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6317427/
https://ncbi.nlm.nih.gov/pubmed/30202884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfy220
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