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Channel Interactions and Robust Inference for Ratiometric β-lactamase Assay Data: a Tox21 Library Analysis.

Ratiometric β-lactamase (BLA) reporters are widely used to study transcriptional responses in a high-throughput screening (HTS) format. Typically, a ratio readout (background/target fluorescence) is used for toxicity assessment and structure-activity modeling efforts from BLA HTS data. This ratio re...

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Udgivet i:ACS Sustain Chem Eng
Main Authors: Melnikov, Fjodor, Hsieh, Jui-Hua, Sipes, Nisha S., Anastas, Paul T.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7252516/
https://ncbi.nlm.nih.gov/pubmed/32461840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acssuschemeng.7b03394
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