Timely double-strand break repair and pathway choice in pericentromeric heterochromatin depend on the histone demethylase dKDM4A

Repair of DNA double-strand breaks (DSBs) must be orchestrated properly within diverse chromatin domains in order to maintain genetic stability. Euchromatin and heterochromatin domains display major differences in histone modifications, biophysical properties, and spatiotemporal dynamics of DSB repa...

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Publicat a:Genes Dev
Autors principals: Janssen, Aniek, Colmenares, Serafin U., Lee, Timothy, Karpen, Gary H.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2019
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6317320/
https://ncbi.nlm.nih.gov/pubmed/30578303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.317537.118
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