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An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders
Identifying disease-associated missense mutations remains a challenge, especially in large-scale sequencing studies. Here we establish an experimentally and computationally integrated approach to investigate the functional impact of missense mutations in the context of the human interactome network...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Nat Genet |
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| Κύριοι συγγραφείς: | , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2018
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6314957/ https://ncbi.nlm.nih.gov/pubmed/29892012 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-018-0130-z |
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