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An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders
Identifying disease-associated missense mutations remains a challenge, especially in large-scale sequencing studies. Here we establish an experimentally and computationally integrated approach to investigate the functional impact of missense mutations in the context of the human interactome network...
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| Publicat a: | Nat Genet |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6314957/ https://ncbi.nlm.nih.gov/pubmed/29892012 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-018-0130-z |
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