Genetic and structural insights into broad neutralization of hepatitis C virus by human V(H)1-69 antibodies

An effective vaccine to the antigenically diverse hepatitis C virus (HCV) must target conserved immune epitopes. Here, we investigate cross-neutralization of HCV genotypes by broadly neutralizing antibodies (bNAbs) encoded by the relatively abundant human gene family V(H)1-69. We have deciphered the...

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發表在:Sci Adv
Main Authors: Tzarum, Netanel, Giang, Erick, Kong, Leopold, He, Linling, Prentoe, Jannick, Augestad, Elias, Hua, Yuanzi, Castillo, Shaun, Lauer, Georg M., Bukh, Jens, Zhu, Jiang, Wilson, Ian A., Law, Mansun
格式: Artigo
語言:Inglês
出版: American Association for the Advancement of Science 2019
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Research Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6314831/
https://ncbi.nlm.nih.gov/pubmed/30613781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aav1882
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