Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation

Organism aging is characterized by increased inflammation and decreased stem cell function, yet the relationship between these factors remains incompletely understood. This study shows that aged hematopoietic stem and progenitor cells (HSPCs) exhibit increased ground-stage NF-κB activity, which enha...

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Vydáno v:J Exp Med
Hlavní autoři: Chen, Zhiyang, Amro, Elias Moris, Becker, Friedrich, Hölzer, Martin, Rasa, Seyed Mohammad Mahdi, Njeru, Sospeter Ngoci, Han, Bing, Di Sanzo, Simone, Chen, Yulin, Tang, Duozhuang, Tao, Si, Haenold, Ronny, Groth, Marco, Romanov, Vasily S., Kirkpatrick, Joanna M., Kraus, Johann M., Kestler, Hans A., Marz, Manja, Ori, Alessandro, Neri, Francesco, Morita, Yohei, Rudolph, K. Lenhard
Médium: Artigo
Jazyk:Inglês
Vydáno: Rockefeller University Press 2019
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6314529/
https://ncbi.nlm.nih.gov/pubmed/30530755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20181505
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