Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation

Organism aging is characterized by increased inflammation and decreased stem cell function, yet the relationship between these factors remains incompletely understood. This study shows that aged hematopoietic stem and progenitor cells (HSPCs) exhibit increased ground-stage NF-κB activity, which enha...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:J Exp Med
Κύριοι συγγραφείς: Chen, Zhiyang, Amro, Elias Moris, Becker, Friedrich, Hölzer, Martin, Rasa, Seyed Mohammad Mahdi, Njeru, Sospeter Ngoci, Han, Bing, Di Sanzo, Simone, Chen, Yulin, Tang, Duozhuang, Tao, Si, Haenold, Ronny, Groth, Marco, Romanov, Vasily S., Kirkpatrick, Joanna M., Kraus, Johann M., Kestler, Hans A., Marz, Manja, Ori, Alessandro, Neri, Francesco, Morita, Yohei, Rudolph, K. Lenhard
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Rockefeller University Press 2019
Θέματα:
Research Articles
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6314529/
https://ncbi.nlm.nih.gov/pubmed/30530755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20181505
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