Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation

Organism aging is characterized by increased inflammation and decreased stem cell function, yet the relationship between these factors remains incompletely understood. This study shows that aged hematopoietic stem and progenitor cells (HSPCs) exhibit increased ground-stage NF-κB activity, which enha...

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Bibliografski detalji
Izdano u:J Exp Med
Glavni autori: Chen, Zhiyang, Amro, Elias Moris, Becker, Friedrich, Hölzer, Martin, Rasa, Seyed Mohammad Mahdi, Njeru, Sospeter Ngoci, Han, Bing, Di Sanzo, Simone, Chen, Yulin, Tang, Duozhuang, Tao, Si, Haenold, Ronny, Groth, Marco, Romanov, Vasily S., Kirkpatrick, Joanna M., Kraus, Johann M., Kestler, Hans A., Marz, Manja, Ori, Alessandro, Neri, Francesco, Morita, Yohei, Rudolph, K. Lenhard
Format: Artigo
Jezik:Inglês
Izdano: Rockefeller University Press 2019
Teme:
Research Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6314529/
https://ncbi.nlm.nih.gov/pubmed/30530755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20181505
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