Inducible down-regulation of MHC class I results in natural killer cell tolerance

Natural killer (NK) cells are innate lymphocytes that are thought to kill cells that down-regulate MHC class I (MHC-I) through “missing-self” recognition. NK cells from B2m(−/−) mice that lack surface MHC-I, however, are not autoreactive as predicted by the missing-self hypothesis. As a result, it i...

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Bibliografiska uppgifter
I publikationen:J Exp Med
Huvudupphovsmän: Bern, Michael D., Parikh, Bijal A., Yang, Liping, Beckman, Diana L., Poursine-Laurent, Jennifer, Yokoyama, Wayne M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Rockefeller University Press 2019
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6314522/
https://ncbi.nlm.nih.gov/pubmed/30559128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20181076
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