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Inducible down-regulation of MHC class I results in natural killer cell tolerance
Natural killer (NK) cells are innate lymphocytes that are thought to kill cells that down-regulate MHC class I (MHC-I) through “missing-self” recognition. NK cells from B2m(−/−) mice that lack surface MHC-I, however, are not autoreactive as predicted by the missing-self hypothesis. As a result, it i...
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| 發表在: | J Exp Med |
|---|---|
| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Rockefeller University Press
2019
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6314522/ https://ncbi.nlm.nih.gov/pubmed/30559128 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20181076 |
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