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Generalized ROC methods for immunogenicity data analysis of vaccine phase I studies in a seropositive population

Immunogenicity data from phase 1 vaccine studies can be difficult to interpret, especially in seropositive populations and when multiple assays are used. We developed 3 statistical methods (Youden index [YI] threshold, receiver-operating characteristic relative to baseline [ROC-B], and ROC of postdo...

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Dades bibliogràfiques
Publicat a:Hum Vaccin Immunother
Autors principals: Yu, Li, Esser, Mark T., Falloon, Judith, Villafana, Tonya, Yang, Harry
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6314430/
https://ncbi.nlm.nih.gov/pubmed/29913105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21645515.2018.1489191
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