YAP1-mediated suppression of USP31 enhances NF-κB activity to promote sarcomagenesis

To date, no consistent oncogenic driver mutations have been identified in most adult soft tissue sarcomas; these tumors are thus generally insensitive to existing targeted therapies. Here we investigated alternate mechanisms underlying sarcomagenesis to identify potential therapeutic interventions....

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Gepubliceerd in:Cancer Res
Hoofdauteurs: Ye, Shuai, Lawlor, Matthew, Rivera-Reyes, Adrian, Egolf, Shaun, Chor, Susan, Pak, Koreana, Ciotti, Gabrielle, Lee, Avery, Marino, Gloria, Shah, Jennifer, Niedzwicki, David, Weber, Kristy, Park, Paul M., Alam, Md. Zahidul, Grazioli, Alison, Haldar, Malay, Xu, Mousheng, Perry, Jennifer A., Qi, Jun, Eisinger-Mathason, T.S. Karin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6314302/
https://ncbi.nlm.nih.gov/pubmed/29490948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-4052
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