Simulations of the regulatory ACT domain of human phenylalanine hydroxylase (PAH) unveil its mechanism of phenylalanine binding

Phenylalanine hydroxylase (PAH) regulates phenylalanine (Phe) levels in mammals to prevent neurotoxicity resulting from high Phe concentrations as observed in genetic disorders leading to hyperphenylalaninemia and phenylketonuria. PAH senses elevated Phe concentrations by transient allosteric Phe bi...

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Pubblicato in:J Biol Chem
Autori principali: Ge, Yunhui, Borne, Elias, Stewart, Shannon, Hansen, Michael R., Arturo, Emilia C., Jaffe, Eileen K., Voelz, Vincent A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6314134/
https://ncbi.nlm.nih.gov/pubmed/30287685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004909
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